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I] Responsible Screening Practices…

According to Tthe SynBio Report, asserts that many though not all commercial gene synthesis firms screen sequences before actually synthesizing DNA synthesis. This Such screening involvesing the comparisong of a sequence to with known “‘dangerous’” sequences, i.e.,  1 sequences which that confer pathogennicitypathogenicity, or which could increase enhance the stabilities stability and persistences of the engineered organism in the environment. Routine Sscreening is routinely carried out accomplished by meansusing of commercially available softwares such aslike the Craic Blackwatch software. However, thisThe system is not not however foolproof,, and updates again and again must always be made to the softwares must be continually updated to so that include recently uncovered identified “‘dangerous’” sequences are included in a screening parameters.  2

Such sScreening practices of this type have evolves evolved independently of regulatory intervention, and an they somehow represent industry standards they represent somehow. The next next step logically are, step is to enforce and evolve these such standards through meaning of appropriate regulation. This can be done achieved on bi two levels:

  • The bBiosafety legislation of in various international nations jurisdictions could be corrected amended to require gene synthesis firms and research organisationsorganizations  3 operating within their territories of jurisdiction to carry out conduct  4 screening for dangerous sequences, to thein accordance with the international industry standard (called the Best -Practice Procedures in the SynBio Report). An independent regulate regulatory body may could be authorisedauthorized by legislation to determine the very largekey aspects of the screening programme, thus allowingwhich would allow the standard to grow big as more information becomes available. This Such a regulatory body should would require need to be confer with research, ers, universities, and all other interested partiesstakeholders before a novel standard is evolved developed and being imposed on companies. Consequently, tThe regulate regulatory body can thuscould be empowered to generate a “‘watching list’” of potentially dangerous sequences, which can then be incorporated into standard screening software.

  • The Cartagena Protocol on Biosafety, a protocol of the Convention on Biological Diversity, may serve serve as the best temp late to regulating regulat synthetic biology on at the international level.

Editor's Comments

編修後的文稿

I] Responsible Screening Practices…

According to Tthe SynBio Report, asserts that many though not all commercial gene synthesis firms screen sequences before actually synthesizing DNA synthesis. This Such screening involvesing the comparisong of a sequence to with known “‘dangerous’” sequences, i.e.,  1 sequences which that confer pathogennicitypathogenicity, or which could increase enhance the stabilities stability and persistences of the engineered organism in the environment. Routine Sscreening is routinely carried out accomplished by meansusing of commercially available softwares such aslike the Craic Blackwatch software. However, thisThe system is not not however foolproof,, and updates again and again must always be made to the softwares must be continually updated to so that include recently uncovered identified “‘dangerous’” sequences are included in a screening parameters.  2

Such sScreening practices of this type have evolves evolved independently of regulatory intervention, and an they somehow represent industry standards they represent somehow. The next next step logically are, step is to enforce and evolve these such standards through meaning of appropriate regulation. This can be done achieved on bi two levels:

  • The bBiosafety legislation of in various international nations jurisdictions could be corrected amended to require gene synthesis firms and research organisationsorganizations  3 operating within their territories of jurisdiction to carry out conduct  4 screening for dangerous sequences, to thein accordance with the international industry standard (called the Best -Practice Procedures in the SynBio Report). An independent regulate regulatory body may could be authorisedauthorized by legislation to determine the very largekey aspects of the screening programme, thus allowingwhich would allow the standard to grow big as more information becomes available. This Such a regulatory body should would require need to be confer with research, ers, universities, and all other interested partiesstakeholders before a novel standard is evolved developed and being imposed on companies. Consequently, tThe regulate regulatory body can thuscould be empowered to generate a “‘watching list’” of potentially dangerous sequences, which can then be incorporated into standard screening software.

  • The Cartagena Protocol on Biosafety, a protocol of the Convention on Biological Diversity, may serve serve as the best temp late to regulating regulat synthetic biology on at the international level.

Editor's Comments

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